Systemic refers to something that is spread throughout, system-wide, affecting a group or system, such as a body, economy, market or society as a whole.
In medicine, systemic means affecting the whole body, or at least multiple organ systems. It is in contrast with topical or local.
Systemic administration, a route of administration of medication so that the entire body is affected
Systemic circulation, carries oxygenated blood from the heart to the body and then returns deoxygenated blood back to the heart
Systemic disease, an illness that affects multiple organs, systems or tissues, or the entire body
Systemic effect, an adverse effect of a medical treatment that affects the body as a whole, rather than one part
Systemic inflammatory response syndrome, an inflammatory state affecting the whole body, frequently in response to infection
Systemic lupus erythematosus, a chronic autoimmune connective tissue disease that can affect any part of the body
Systemic scleroderma, also known as systemic sclerosis, a systemic connective tissue disease
Systemic venous system, refers to veins that drain into the right atrium without passing through two vascular beds
Systemic exertion intolerance disease, a new name for chronic fatigue syndrome
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